Biophysical investigations elucidating the mechanisms of action of antimicrobial peptides and their synergism
A Marquette, B Bechinger - Biomolecules, 2018 - mdpi.com
Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …
Effect of hydrophobic modifications in antimicrobial peptides
With increasing resistance development against conventional antibiotics, there is an urgent
need to identify novel approaches for infection treatment. Antimicrobial peptides may offer …
need to identify novel approaches for infection treatment. Antimicrobial peptides may offer …
Two distinct amphipathic peptide antibiotics with systemic efficacy
J Lakshmaiah Narayana, B Mishra… - Proceedings of the …, 2020 - National Acad Sciences
Antimicrobial peptides are important candidates for develo** new classes of antibiotics
because of their potency against antibiotic-resistant pathogens. Current research focuses on …
because of their potency against antibiotic-resistant pathogens. Current research focuses on …
The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations
C Aisenbrey, A Marquette, B Bechinger - Antimicrobial Peptides: Basics …, 2019 - Springer
Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …
how these peptides interact with membranes can still bear surprises and add new …
Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis
The synthetic cyclic hexapeptide cWFW (cyclo (RRRWFW)) has a rapid bactericidal activity
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …
Solid‐state NMR spectroscopy on complex biomolecules
M Renault, A Cukkemane… - Angewandte Chemie …, 2010 - Wiley Online Library
Biomolecular applications of NMR spectroscopy are often merely associated with soluble
molecules or magnetic resonance imaging. However, since the late 1970s, solid‐state NMR …
molecules or magnetic resonance imaging. However, since the late 1970s, solid‐state NMR …
Biomembrane lipids: When physics and chemistry join to shape biological activity
Biomembranes constitute the first lines of defense of cells. While small molecules can often
permeate cell walls in bacteria and plants, they are generally unable to penetrate the barrier …
permeate cell walls in bacteria and plants, they are generally unable to penetrate the barrier …
The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy
B Bechinger, ES Salnikov - Chemistry and physics of lipids, 2012 - Elsevier
Solid-state NMR spectroscopic techniques provide valuable information about the structure,
dynamics and topology of membrane-inserted polypeptides. In particular antimicrobial …
dynamics and topology of membrane-inserted polypeptides. In particular antimicrobial …
Probing the “charge cluster mechanism” in amphipathic helical cationic antimicrobial peptides
Clustering of anionic lipids away from zwitterionic ones by cationic antimicrobial agents has
recently been established as a mechanism of action of natural small, flexible peptides as …
recently been established as a mechanism of action of natural small, flexible peptides as …
Role of lipid composition, physicochemical interactions, and membrane mechanics in the molecular actions of microbial cyclic lipopeptides
Several experimental and theoretical studies have extensively investigated the effects of a
large diversity of antimicrobial peptides (AMPs) on model lipid bilayers and living cells …
large diversity of antimicrobial peptides (AMPs) on model lipid bilayers and living cells …