The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

This article discusses data showing that mammals, including humans, have two sources of
melatonin that exhibit different functions. The best-known source of melatonin, herein …

Melatonin is an ancient molecule that is evident in high concentrations in various tissues
throughout the body. It can be separated into two pools; one of which is synthesized by the …

Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high
mortality rates. Its pathophysiology involves complex factors, including inflammatory …

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient
oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron …

Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown
various antitumor properties. Herein, we investigated the influence of melatonin therapy on …

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and
recurrent course, which significantly reduces the quality of life. Sleep disturbances are …

Much attention has been recently drawn to studying melatonin–a hormone whose synthesis
was first found in the epiphysis (pineal gland). This interest can be due to discovering the …

Cell-to-cell communication is a broad and complex process associated with regular stimuli
to maintain healthy cell interactions. One of the agents capable of cellular communication is …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …