Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Background Alzheimer disease (AD) is the most common form of dementia but the
identification of reliable, early and non-invasive biomarkers remains a major challenge. We …

The link between dysregulated serotonergic activity and depression and anxiety disorders is
well established, yet the molecular mechanisms underlying these psychopathologies are not …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in
the brain, and is one of the most widely investigated molecule in psychiatric disorders. The …

Major depressive disorder (MDD) is a prevalent mood disorder that is associated with
differential prefrontal brain expression patterns. Treatment of MDD includes a variety of …

Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since
it is one of the most highly expressed microRNAs in the develo** and adult vertebrate …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Background There is growing evidence for a role of the gut microbiome in sha**
behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using …