[HTML][HTML] Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - Elsevier
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

[HTML][HTML] Manganese-induced parkinsonism and Parkinson's disease: shared and distinguishable features

GF Kwakye, MMB Paoliello, S Mukhopadhyay… - International journal of …, 2015 - mdpi.com
Manganese (Mn) is an essential trace element necessary for physiological processes that
support development, growth and neuronal function. Secondary to elevated exposure or …

When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms

P Vaudin, C Augé, N Just, S Mhaouty-Kodja… - Environmental …, 2022 - Elsevier
Pharmaceutical drugs have become consumer products, with a daily use for some of them.
The volume of production and consumption of drugs is such that they have become …

Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents

MJ Lubczyńska, RL Muetzel, H El Marroun… - Environmental …, 2021 - Elsevier
Background Studies investigating the relationship between exposure to air pollution and
brain development using magnetic resonance images are emerging. However, most studies …

[HTML][HTML] Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms

I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …

Manganese exposure and neurocognitive outcomes in rural school-age children: the communities actively researching exposure study (Ohio, USA)

EN Haynes, H Sucharew, P Kuhnell… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Manganese (Mn) plays a vital role in brain growth and development, yet
excessive exposure can result in neurotoxicity. Marietta, Ohio, is home to the nation's …

Biomarkers for occupational manganese exposure

NA Karyakina, N Shilnikova, N Farhat… - Critical Reviews in …, 2022 - Taylor & Francis
Long-term inhalation exposure to manganese (Mn) metal or its inorganic compounds can
result in manganism or subclinical neurofunctional deficits. Studies have described affected …

Associations of air pollution on the brain in children: a brain imaging study

M Guxens, MJ Lubczyńska… - Research Reports …, 2022 - pmc.ncbi.nlm.nih.gov
BACKGROUND Although several epidemiological studies have assessed the association
between air pollution exposure during early life and child neurological development, it is yet …

[HTML][HTML] The cGAS-STING-mediated NLRP3 inflammasome is involved in the neurotoxicity induced by manganese exposure

J Liu, X Zhang, H Wang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Heavy metal pollution has become a global health challenge. Exposure to heavy metals
represents a major health risk. Manganese (Mn) is an essential trace element but also an …

Airborne manganese exposure and neurobehavior in school-aged children living near a ferro-manganese alloy plant

JLG Rodrigues, CFS Araújo, NR Dos Santos… - Environmental …, 2018 - Elsevier
Excessive exposure to Mn can lead to its accumulation in the brain with neurotoxic
consequences. In children, elevated Mn has been associated with deficits in certain …