Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

Purpose: FGFR inhibitors are effective in FGFR2-altered cholangiocarcinoma, leading to
approval of reversible FGFR inhibitors, pemigatinib and infigratinib, and an irreversible …

Purpose: Understanding resistance to selective FGFR inhibitors is crucial to improve the
clinical outcomes of patients with FGFR2-driven malignancies. Experimental Design: We …

Fibrosarcoma, a malignant mesenchymal tumor, is characterized by aggressive
invasiveness and a high recurrence rate, leading to poor prognosis. Anthracycline drugs …

Precision oncology has a significant role to play in delivering optimal patient care.
Biomarkers are critical enablers for precision oncology across the continuum of cancer …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Abstract Purpose of Review Molecular profiling enables the evaluation of genetic alterations
for the diagnosis and classification of gliomas and the selection of appropriate therapies …

Background: Diagnostic classification of thyroid malignancy is primarily accomplished
through examination of histomorphological features and may be substantiated and clarified …

Precision medicine is a major achievement that has impacted on management of patients
diagnosed with advanced cholangiocarcinoma (CCA) over the last decade. Molecular …