The regulation of hyphae growth in Candida albicans

H Chen, X Zhou, B Ren, L Cheng - Virulence, 2020 - Taylor & Francis
In the last decades, Candida albicans has served as the leading causal agent of life-
threatening invasive infections with mortality rates approaching 40% despite treatment …

Growth of Candida albicans hyphae

PE Sudbery - Nature Reviews Microbiology, 2011 - nature.com
The fungus Candida albicans is often a benign member of the mucosal flora; however, it
commonly causes mucosal disease with substantial morbidity and in vulnerable patients it …

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

N Zhou, Y Jiang, TR Bergquist, AJ Lee, BZ Kacsoh… - Genome biology, 2019 - Springer
Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an
ongoing, global, community-driven effort to evaluate and improve the computational …

Mechanism of Candida pathogenesis: revisiting the vital drivers

IE Mba, EI Nweze - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …

Candida albicans dimorphism as a therapeutic target

ID Jacobsen, D Wilson, B Wächtler… - Expert review of anti …, 2012 - Taylor & Francis
The ability to switch between yeast and hyphal growth forms (dimorphism) is one of the most
discussed and best investigated virulence attributes of the human pathogenic fungus …

[HTML][HTML] Invasive candidiasis: update and current challenges in the management of this mycosis in South America

FO Riera, JP Caeiro, SC Angiolini, C Vigezzi… - Antibiotics, 2022 - mdpi.com
Invasive candidiasis encompassing Candida bloodstream infections and deep-seated
candidiasis can become a persistent health problem. These infections are caused by …

Mechanisms of fungal dissemination

AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

[HTML][HTML] Candida albicans interactions with epithelial cells and mucosal immunity

JR Naglik, DL Moyes, B Wächtler, B Hube - Microbes and infection, 2011 - Elsevier
Candida albicans interactions with epithelial cells are critical for commensal growth, fungal
pathogenicity and host defence. This review will outline our current understanding of C …

Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans

S Mogavero, FM Sauer, S Brunke, S Allert… - Cellular …, 2021 - Wiley Online Library
The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections.
Although the ability to transition from the yeast to the hypha morphology is essential for …

Candida survival strategies

M Polke, B Hube, ID Jacobsen - Advances in Applied Microbiology, 2015 - Elsevier
Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …