Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-
methyl-d-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the …

Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of
homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the …

Despite the absence of responsiveness during anesthesia, conscious experience may
persist. However, reliable, easily acquirable and interpretable neurophysiological markers of …

Ketamine produces rapid and sustained antidepressant actions in depressed patients, but
the precise cellular mechanisms underlying these effects have not been identified. Here we …

Objectives Ketamine is an N-methyl-d-aspartate (NMDA) receptor antagonist commonly
administered as a general anesthetic. However, neural circuit mechanisms to explain …

The neural correlates of consciousness must be identified, but how? Anesthetics can be
used as tools to dissect the nervous system. Anesthetics not only allow for the experimental …

Recent reports of a rapid antidepressant effect of the glutamate N‐methyl‐d‐aspartate
(NMDA) receptor antagonist ketamine, even in treatment‐resistant populations, have …

Physiological activation increases glucose uptake locally in the brain. However, it is not
known how high intensity exercise affects regional and global brain glucose uptake. The …

BACKGROUND: A key to successful adaptation is the ability to regulate emotional
responses in relation to changing environmental demands or contexts. METHODS: High …