Epigenetic modifications and human disease
A Portela, M Esteller - Nature biotechnology, 2010 - nature.com
Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …
Rett syndrome: insights into genetic, molecular and circuit mechanisms
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …
MicroRNAs in neuronal function and dysfunction
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …
Aberrant epigenetic landscape in cancer: how cellular identity goes awry
M Berdasco, M Esteller - Developmental cell, 2010 - cell.com
Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …
microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance
MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–
22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in …
22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in …
Psychosis and autism as diametrical disorders of the social brain
B Crespi, C Badcock - Behavioral and brain sciences, 2008 - cambridge.org
Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia,
bipolar disorder, and major depression) represent two major suites of disorders of human …
bipolar disorder, and major depression) represent two major suites of disorders of human …
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes
MicroRNAs (miRNAs) have been shown to play important roles in both brain development
and the regulation of adult neural cell functions. However, a systematic analysis of brain …
and the regulation of adult neural cell functions. However, a systematic analysis of brain …
MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases
MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …
[HTML][HTML] Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation
Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-
mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency …
mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency …
Identification and functional characterization of microRNAs involved in the malignant progression of gliomas
B Malzkorn, M Wolter, F Liesenberg… - Brain …, 2010 - Wiley Online Library
Abstract Diffuse astrocytoma of World Health Organization (WHO) grade II has an inherent
tendency to spontaneously progress to anaplastic astrocytoma WHO grade III or secondary …
tendency to spontaneously progress to anaplastic astrocytoma WHO grade III or secondary …