The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

The underlying cause of aging remains one of the central mysteries of biology. Recent
studies in several different systems suggest that not only may the rate of aging be modified …

The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the
laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic …

The biology and behavior of adults differ substantially from those of develo** animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

Cell-cell communication within the follicle involves many signaling molecules, and this
process may be mediated by secretion and uptake of exosomes that contain several …

In post-reproductive C. elegans, destructive somatic biomass repurposing supports
production of yolk which, it was recently shown, is vented and can serve as a foodstuff for …

Insulin/insulin-like growth factor signalling (IIS) is a critical regulator of an organism's most
important biological decisions from growth, development, and metabolism to reproduction …

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for
identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

The transforming growth factor (TGF)-β and phosphoinositide 3-kinase/protein kinase B
(PI3K/AKT) signaling pathways are used in cells to control numerous responses, including …