[HTML][HTML] Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis
Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …
involved in the formation and elimination of reactive oxygen species. However, it is …
[HTML][HTML] Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is
produced chiefly by the liver and kidney. It presents in different organs, including retina …
produced chiefly by the liver and kidney. It presents in different organs, including retina …
Most reported genetic associations with general intelligence are probably false positives
General intelligence (g) and virtually all other behavioral traits are heritable. Associations
between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes …
between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes …
Inborn errors of metabolism
Inborn errors of metabolism, also known as inherited metabolic diseases, constitute an
important group of conditions presenting with neurologic signs in newborns. They are …
important group of conditions presenting with neurologic signs in newborns. They are …
γ-Hydroxybutyric acid: pharmacokinetics, pharmacodynamics, and toxicology
MA Felmlee, BL Morse, ME Morris - The AAPS journal, 2021 - Springer
Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid present endogenously in the brain
and used therapeutically for the treatment of narcolepsy, as sodium oxybate, and for alcohol …
and used therapeutically for the treatment of narcolepsy, as sodium oxybate, and for alcohol …
The presence and severity of epilepsy coincide with reduced γ‐aminobutyrate and cortical excitatory markers in succinic semialdehyde dehydrogenase deficiency
I Tokatly Latzer, M Bertoldi, ML DiBacco, E Arning… - …, 2023 - Wiley Online Library
Objective Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare inherited
metabolic disorder caused by a defect of γ‐aminobutyrate (GABA) catabolism. Despite the …
metabolic disorder caused by a defect of γ‐aminobutyrate (GABA) catabolism. Despite the …
Neuropathological mechanisms of seizures in autism spectrum disorder
This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD)
and epilepsy. Two neuropathological findings are shared by ASD and epilepsy …
and epilepsy. Two neuropathological findings are shared by ASD and epilepsy …
SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration
Succinate dehydrogenase (SDH) occupies a central place in cellular energy production,
linking the tricarboxylic cycle with the electron transport chain. As a result, a subset of …
linking the tricarboxylic cycle with the electron transport chain. As a result, a subset of …
A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel
Despite the fact that seizures are commonly associated with autism spectrum disorder
(ASD), the effectiveness of treatments for seizures has not been well studied in individuals …
(ASD), the effectiveness of treatments for seizures has not been well studied in individuals …
Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of …
Discovered some 35 years ago, succinic semialdehyde dehydrogenase deficiency
(SSADHD) represents a rare, autosomal recessively-inherited defect in the second step of …
(SSADHD) represents a rare, autosomal recessively-inherited defect in the second step of …