Challenges in exploiting human H ferritin nanoparticles for drug delivery: navigating physiological constraints

A Macone, C Cappelletti, A Incocciati… - Wiley …, 2024 - Wiley Online Library
Over the past two decades, ferritin has emerged as a promising nanoparticle for drug
delivery, catalyzing the development of numerous prototypes capable of encapsulating a …

Combined ferritin nanocarriers with ICG for effective phototherapy against breast cancer

L Sitia, P Saccomandi, L Bianchi, M Sevieri… - International Journal …, 2024 - Taylor & Francis
Introduction Photodynamic Therapy (PDT) is a promising, minimally invasive treatment for
cancer with high immunostimulatory potential, no reported drug resistance, and reduced …

Design and application of ferritin-based nanomedicine for targeted cancer therapy

B Zhang, K Fan - Nanomedicine, 2025 - Taylor & Francis
Owing to its unique structure and favorable biocompatibility, ferritin has been widely studied
as a promising drug carrier over the past two decades. Since the identification of its inherent …

Hydrophobicity‐enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells

A Incocciati, J Kubeš, R Piacentini… - Protein …, 2023 - Wiley Online Library
Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug
delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic …

[HTML][HTML] Gold nanoparticles in transferrin-targeted dual-drug delivery in vitro

LL David, A Daniels, S Habib, M Singh - Journal of Drug Delivery Science …, 2023 - Elsevier
Nanotechnology has significantly impacted medicine by improving diagnostics and
therapeutics. By modifying materials at the nanoscale, we can impart unique and desirable …

Development of a ferritin protein nanoparticle vaccine with PRRSV GP5 protein

X Chang, J Ma, Y Zhou, S **ao, X **ao, L Fang - Viruses, 2024 - mdpi.com
Porcine reproductive and respiratory syndrome virus (PRRSV) presents a significant threat
to the global swine industry. The development of highly effective subunit nanovaccines is a …

Semisynthetic ferritin-based nanoparticles with high magnetic anisotropy for spatial magnetic manipulation and inductive heating

A Neusch, U Wiedwald, IP Novoselova, DA Kuckla… - Nanoscale, 2024 - pubs.rsc.org
The human iron storage protein ferritin represents an appealing template to obtain a
semisynthetic magnetic nanoparticle (MNP) for spatial manipulation or inductive heating …

Autologous material-inspired drug delivery systems

H Feng, I Cheng, F Liu, Z Gu, H Li - Science China Materials, 2024 - Springer
Pursuing personalized medicine has spurred the development of drug delivery systems
inspired by autologous materials, underscoring the transition from natural origins to …

Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome

F Tiberio, M Salvati, L Polito, G Tisci, A Vita… - … Therapy Nucleic Acids, 2025 - cell.com
Crouzon syndrome is a rare genetic craniofacial malformation caused by heterozygous gain-
of-function mutations in the FGFR2 gene. The resulting constitutive activation of the FGFR2 …

[HTML][HTML] A Brief History of Ferritin, an Ancient and Versatile Protein

P Arosio, G Cairo, F Bou-Abdallah - International Journal of Molecular …, 2024 - mdpi.com
Ferritin, a highly conserved iron storage protein, is among the earliest proteins that have
been purified, named, and characterized due to its unique properties that continue to …