The zinc finger antiviral protein (ZAP) restricts the replication of a broad range of RNA and
DNA viruses. ZAP directly binds viral RNA, targeting it for degradation and inhibiting its …

The CCCH-type zinc finger antiviral protein (ZAP) in humans, specifically isoforms ZAP-L
and ZAP-S, is a crucial component of the cell's intrinsic immune response. ZAP acts as a …

Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …

Recent evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is sensitive to interferons (IFNs). However, the most effective types of IFNs and the …

Large-scale re-engineering of synonymous sites is a promising strategy to generate
vaccines either through synthesis of attenuated viruses or via codon-optimized genes in …

Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses
through undefined molecular mechanisms. IFITM3 localizes in the endosomal-lysosomal …

Safe and effective vaccines are urgently needed to stop the pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live …

Drug resistance reflects the evolution of tumors, which is the main cause of recurrence and
death. Currently, EGFR-TKI treatment is the first-line therapy for lung adenocarcinoma …

Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious
disease and widespread epidemics. To develop virus-specific therapies, it is critical to …

The zinc finger antiviral protein (ZAP) is a broad inhibitor of virus replication. Its best-
characterized function is to bind CpG dinucleotides present in viral RNAs and, through the …