RAVEN is a commonly used MATLAB toolbox for genome-scale metabolic model (GEM)
reconstruction, curation and constraint-based modelling and simulation. Here we present …

Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the
genus Leishmania. The disease has more than one clinical forms and the visceral form is …

Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …

Introduction Visceral leishmaniasis (VL) is caused by Leishmania donovani. The purine and
pyrimidine pathways are essential for L. donovani. Simultaneously inhibiting multiple targets …

In this work, a magnetic bio-metal–organic framework (MBMOF) nanocomposite with porous-
layer open morphology is synthesized through a simple sonochemical approach and its …

Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …

Leishmaniasis is the second deadliest vector-borne, neglected tropical zoonotic disease
and is found in a variety of clinical forms based on genetic background. Its endemic type is …

Highlights•Genome-scale metabolic network reconstructions capture human pathogen
phenotypes.•Reconstructions can explore relationships between drug resistance and …

Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania
infantum is one of main disease causative agents in the Americas. In a previous …

Leishmaniases are neglected diseases that can be treated with a limited drug arsenal; the
development of new molecules is therefore a priority. Recent evidence indicates that …