Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

Magnetic resonance imaging (MRI) uses a large magnetic field and radio waves to generate
images of tissues in the body. Conventional MRI techniques have been developed to image …

Multiexponential T2 relaxation time measurement in the central nervous system shows a
component that originates from water trapped between the lipid bilayers of myelin. This …

Myelin water imaging (MWI) is an MRI imaging biomarker for myelin. This method can
generate an in vivo whole‐brain myelin water fraction map in approximately 10 minutes. It …

Purpose To characterize a new approach to magnetization transfer (MT) imaging with
improved specificity for myelinated tissues relative to conventional MT. Methods …

The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

Current studies related to lipid identification and determination, or lipidomics in biological
samples, are one of the most important issues in modern bioanalytical chemistry. There are …

Hypomyelinating leukodystrophies represent a genetically heterogeneous but clinically
overlap** group of heritable disorders. Current management approaches in the care of …

White matter of the brain contains a majority of long T2 components as well as a minority of
short T2 components. These are not detectable using clinical magnetic resonance imaging …

Among current modalities of biomedical and diagnostic imaging, MRI stands out by virtue of
its versatile contrast obtained without ionizing radiation. However, in various cases, eg …