Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in sha** immune responses and host defense during infection
Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
Ubiquitination-proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress
Y Li, S Li, H Wu - Cells, 2022 - mdpi.com
In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …
injury, repair the damage, and increase the tolerance to the stress. However, once the …
[HTML][HTML] MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
GKL Chan, S Maisel, YC Hwang, BC Pascual… - Elife, 2023 - elifesciences.org
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet,
their downstream oncogenic signaling mechanisms are poorly understood. We used global …
their downstream oncogenic signaling mechanisms are poorly understood. We used global …
Perspectives and Advances in the Understanding of Tuberculosis
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …
leading cause of death due to infection in humans. To more effectively combat this …
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases
worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence …
worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence …
Understanding the tuberculosis granuloma: the matrix revolutions
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains
the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore …
the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore …
IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the
cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ …
cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ …
Breaching the phagosome, the case of the tuberculosis agent
R Simeone, F Sayes, E Lawarée… - Cellular …, 2021 - Wiley Online Library
The interactions between microbes and their hosts are among the most complex biological
phenomena known today. The interaction may reach from overall beneficial interaction, as …
phenomena known today. The interaction may reach from overall beneficial interaction, as …