SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

Pgp (P-glycoprotein)(ABCB1) is an ATP-powered efflux pump which can transport hundreds
of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

ABC transporters mediate active translocation of a diverse range of molecules across all cell
membranes. They comprise two nucleotide-binding domains (NBDs) and two …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

▪ Abstract ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and
efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these …

The ATP-binding cassette subfamily B member 1 (ABCB1) multidrug transporter P-
glycoprotein plays a central role in clearance of xenobiotics in humans and is implicated in …

ATP-binding cassette (ABC) transporter proteins carry diverse substrates across cell
membranes. Whereas clinically relevant ABC exporters are implicated in various diseases …

Membrane proteins responsible for the active efflux of structurally and functionally unrelated
drugs were first characterized in higher eukaryotes. To date, a vast number of transporters …

ATP binding cassette transporters are ubiquitous integral membrane proteins that actively
transport ligands across biological membranes, a process critical for most aspects of cell …