Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics

MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Advances in MALDI mass spectrometry imaging single cell and tissues

X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

MALDI-2 on a trapped ion mobility quadrupole time-of-flight instrument for rapid mass spectrometry imaging and ion mobility separation of complex lipid profiles

J Soltwisch, B Heijs, A Koch, S Vens-Cappell… - Analytical …, 2020 - ACS Publications
Matrix-assisted laser desorption/ionization combined with laser-induced postionization
(MALDI-2) is a recently introduced method for enhanced mass spectrometry imaging of …

MALDI-MSI towards multimodal imaging: challenges and perspectives

M Tuck, F Grélard, L Blanc, N Desbenoit - Frontiers in Chemistry, 2022 - frontiersin.org
Multimodal imaging is a powerful strategy for combining information from multiple images. It
involves several fields in the acquisition, processing and interpretation of images. As …

A new update of MALDI-TOF mass spectrometry in lipid research

KM Engel, P Prabutzki, J Leopold, A Nimptsch… - Progress in lipid …, 2022 - Elsevier
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …

Considerations for MALDI-based quantitative mass spectrometry imaging studies

F Tobias, AB Hummon - Journal of proteome research, 2020 - ACS Publications
Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …

Multimodal imaging based on vibrational spectroscopies and mass spectrometry imaging applied to biological tissue: a multiscale and multiomics review

M Tuck, L Blanc, R Touti, NH Patterson… - Analytical …, 2020 - ACS Publications
Molecular imaging has the potential to unearth important spatial and temporal relationships
in biological systems, including intercellular signaling as well as environmentally-cued …

A five-year update on matrix compounds for MALDI-MS analysis of lipids

J Leopold, P Prabutzki, KM Engel, J Schiller - Biomolecules, 2023 - mdpi.com
Matrix-assisted laser desorption and ionization (MALDI) is a widely used soft-ionization
technique of modern mass spectrometry (MS). MALDI enables the analysis of nearly all …