RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
How RNA-binding proteins interact with RNA: molecules and mechanisms
M Corley, MC Burns, GW Yeo - Molecular cell, 2020 - cell.com
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
S Zhao, Y Mi, B Guan, B Zheng, P Wei, Y Gu… - Journal of hematology & …, 2020 - Springer
Background Mounting evidence has demonstrated the vital importance of tumor-associated
macrophages (TAMs) and exosomes in the formation of the premetastatic niche. However …
macrophages (TAMs) and exosomes in the formation of the premetastatic niche. However …
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling …
S Zhao, Y Mi, B Zheng, P Wei, Y Gu… - Journal of …, 2022 - Wiley Online Library
Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related
mortality, and is typically caused by interactions between CRC cells and the tumour …
mortality, and is typically caused by interactions between CRC cells and the tumour …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides
Liquid-liquid phase separation of multivalent proteins and RNAs drives the formation of
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …
Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5
X Qin, H Guo, X Wang, X Zhu, M Yan, X Wang, Q Xu… - Genome biology, 2019 - Springer
Background Cisplatin resistance is a major challenge for advanced head and neck cancer
(HNC). Understanding the underlying mechanisms and develo** effective strategies …
(HNC). Understanding the underlying mechanisms and develo** effective strategies …
Cytoplasmic functions of long noncoding RNAs
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
throughout the cell that lack protein‐coding function. Their functions are closely linked to …
A census of human RNA-binding proteins
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
Predicting the sequence specificities of DNA-and RNA-binding proteins by deep learning
Knowing the sequence specificities of DNA-and RNA-binding proteins is essential for
develo** models of the regulatory processes in biological systems and for identifying …
develo** models of the regulatory processes in biological systems and for identifying …