Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Endogenous Cushing's syndrome results from excess glucocorticoid secretion, which leads
to a myriad of clinical manifestations, comorbidities, and increased mortality despite …

An adrenal incidentaloma is now established as a common endocrine diagnosis that
requires a multidisciplinary approach for effective management. The majority of patients can …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

The incidence of biliary tract cancer (BTC), including intrahepatic (ICC) and extrahepatic
(ECC) cholangiocarcinoma and gallbladder cancer, has increased globally; however, no …

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC).
Using this dataset, we expand the catalogue of known ACC driver genes to include …

Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by
pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and …