Virus infections and autoimmune disease have long been linked. These infections often
precede the occurrence of inflammation in the target organ. Several mechanisms often used …

As a group of disorders, autoimmunity ranks as the third most prevalent cause of morbidity
and mortality in the W estern W orld. However, the etiology of most autoimmune diseases …

During immune responses, T cells are subject to clonal competition, which leads to the
predominant expansion of high-affinity clones; however, there is little understanding of how …

After an infection, T cells that carry the CD8 marker are activated and undergo a
characteristic kinetic sequence of rapid expansion, subsequent contraction and formation of …

The predisposition of individuals to several common autoimmune diseases, such as
rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically …

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor
regression, but they often also are accompanied by autoimmune responses. To determine …

Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors
within the tumor microenvironment and eliciting tumor regression. We have found that Cish …

Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

T cells causing autoimmunity must escape tolerance. We observed that CD8+ T cells with
high avidity for an antigen expressed in the pancreas, kidney, and thymic medulla were …