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IgA nephropathy
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …
Mendelian randomization as an approach to assess causality using observational data
Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …
observed association between a modifiable exposure or risk factor and a clinically relevant …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
[HTML][HTML] Results of a randomized double-blind placebo-controlled Phase 2 study propose iptacopan as an alternative complement pathway inhibitor for IgA …
Targeting the alternative complement pathway is an attractive therapeutic strategy given its
role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Iptacopan (LNP023) is …
role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Iptacopan (LNP023) is …
IgA nephropathy: an interesting autoimmune kidney disease
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
IgA nephropathy
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding …
collaborative efforts have led to important discoveries that have improved our understanding …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
[HTML][HTML] Pathogenesis of IgA vasculitis: an up-to-date review
Y Song, X Huang, G Yu, J Qiao, J Cheng, J Wu… - Frontiers in …, 2021 - frontiersin.org
Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura
(HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at …
(HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at …
IgA nephropathy
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
[HTML][HTML] Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies …
J Floege, SJ Barbour, DC Cattran, JJ Hogan… - Kidney international, 2019 - Elsevier
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a
Controversies Conference on glomerular diseases in November 2017. The conference …
Controversies Conference on glomerular diseases in November 2017. The conference …