Aging-associated cardiovascular changes and their relationship to heart failure

JB Strait, EG Lakatta - Heart failure clinics, 2012 - heartfailure.theclinics.com
Although aging does not itself cause heart failure (HF), it does lower the threshold for
manifestation of the disease. As the populations of most developed countries continue to …

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease

EG Lakatta, D Levy - Circulation, 2003 - Am Heart Assoc
produces an exaggerated A wave. The augmented atrial contraction is accompanied by
atrial hypertrophy and enlargement and on auscultation is manifested as a fourth heart …

Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons

EG Lakatta - Heart failure reviews, 2002 - Springer
Abstract In the United States, cardiovascular disease, eg, atherosclerosis and hypertension,
that lead to heart failure and stroke, is the leading cause of mortality, accounting for over 40 …

How to assess sympathetic activity in humans

G Grassi, M Esler - Journal of hypertension, 1999 - journals.lww.com
Sympathetic factors play a central role not only in cardiovascular homeostatic control but
also in the pathogenesis and/or in the progression of several cardiovascular diseases, such …

Ageing and the border between health and disease

W MacNee, RA Rabinovich… - European Respiratory …, 2014 - Eur Respiratory Soc
Ageing is associated with a progressive degeneration of the tissues, which has a negative
impact on the structure and function of vital organs and is among the most important known …

Human ageing and the sympathoadrenal system

DR Seals, MD Esler - The Journal of physiology, 2000 - Wiley Online Library
Over the past three decades the changes in sympathoadrenal function that occur with age in
healthy adult humans have been systematically studied using a combination of …

The aged cardiovascular risk patient

HJ Priebe - British journal of anaesthesia, 2000 - bjanaesthesia.org
There is no precise definition of'the aged','the elderly'or'advanced age'. This is hardly
surprising, because there is no specific clinical marker of the'geriatric'patient, and ageing …

Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications

MJ Joyner, N Charkoudian, BG Wallin - Hypertension, 2010 - Am Heart Assoc
The autonomic nervous system and its sympathetic arm play important roles in the
regulation of blood pressure. 1–3 Their role in the short-term regulation of blood pressure …

Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure

B Rundqvist, M Elam, Y Bergmann-Sverrisdottir… - Circulation, 1997 - Am Heart Assoc
Background Previous studies with radiotracer methods have indicated increases in cardiac
norepinephrine (NE) and renal NE spillover in patients with severe congestive heart failure …

The role of exercise in cardiac aging: from physiology to molecular mechanisms

J Roh, J Rhee, V Chaudhari, A Rosenzweig - Circulation research, 2016 - Am Heart Assoc
Aging induces structural and functional changes in the heart that are associated with
increased risk of cardiovascular disease and impaired functional capacity in the elderly …