Left ventricular assist devices: a rapidly evolving alternative to transplant

D Mancini, PC Colombo - Journal of the American College of Cardiology, 2015‏ - jacc.org
Left ventricular assist devices are becoming an increasingly prevalent therapy for patients
with Stage D heart failure with reduced ejection fraction. Technological advances have …

Shear-induced acquired von Willebrand syndrome: an accomplice of bleeding events in adults on extracorporeal membrane oxygenation support

H Wang, D Li, Y Chen, Z Liu, Y Liu, X Meng… - Frontiers in …, 2023‏ - frontiersin.org
Extracorporeal membrane oxygenation (ECMO) is an increasingly acceptable life-saving
mechanical assistance system that provides cardiac and/or respiratory support for several …

Arterial pulsatility and circulating von Willebrand factor in patients on mechanical circulatory support

F Vincent, A Rauch, V Loobuyck, E Robin, C Nix… - Journal of the American …, 2018‏ - jacc.org
Background: The main risk factor for bleeding in patients with continuous-flow mechanical
circulatory support (CF-MCS) is the acquired von Willebrand factor (VWF) defect related to …

Shear stress and blood trauma under constant and pulse-modulated speed CF-VAD operations: CFD analysis of the HVAD

Z Chen, SK Jena, GA Giridharan, MA Sobieski… - Medical & biological …, 2019‏ - Springer
Modulation of pump speed has been proposed and implemented clinically to improve
vascular pulsatility in continuous flow ventricular assist device patient. The flow dynamics of …

Left ventricular assist devices: current controversies and future directions

EM Schumer, MC Black, G Monreal… - European Heart …, 2016‏ - academic.oup.com
Advanced heart failure is a growing epidemic that leads to significant suffering and
economic losses. The development of left ventricular assist devices (LVADs) has led to …

Clinical implications of physiologic flow adjustment in continuous-flow left ventricular assist devices

V Tchantchaleishvili, JGY Luc, CM Cohan, K Phan… - Asaio …, 2017‏ - journals.lww.com
There is increasing evidence for successful management of end-stage heart failure with
continuous-flow left ventricular assist device (CF-LVAD) technology. However, passive flow …

Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

L Liang, X Wang, D Chen, P Sethu, GA Giridharan… - Lab on a Chip, 2024‏ - pubs.rsc.org
Rotary blood pumps (RBPs) operating at a constant speed generate non-physiologic blood
pressure and flow rate, which can cause endothelial dysfunction, leading to adverse clinical …

In vivo evaluation of physiologic control algorithms for left ventricular assist devices based on left ventricular volume or pressure

G Ochsner, MJ Wilhelm, R Amacher, A Petrou… - Asaio …, 2017‏ - journals.lww.com
Turbodynamic left ventricular assist devices (LVADs) provide a continuous flow depending
on the speed at which the pump is set, and do not adapt to the changing requirements of the …

Feasibility of pump speed modulation for restoring vascular pulsatility with rotary blood pumps

MS Ising, MA Sobieski, MS Slaughter, SC Koenig… - Asaio …, 2015‏ - journals.lww.com
Continuous flow (CF) left ventricular assist devices (LVAD) diminish vascular pressure
pulsatility, which may be associated with clinically reported adverse events including …

Advances in hemodynamic analysis in cardiovascular diseases investigation of energetic characteristics of adult and pediatric sputnik left ventricular assist devices …

AA Pugovkin, AG Markov, SV Selishchev… - Cardiology …, 2019‏ - Wiley Online Library
The need to simulate the operating conditions of the human body is a key factor in every
study and engineering process of a bioengineering device developed for implantation. In the …