Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to
subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been …

Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …

Recently, organoid technology has been used to generate a large repository of breast
cancer organoids. Here we present an extensive evaluation of the ability of organoid culture …

Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form
tumours,–. Yet, the underlying protection mechanisms are largely unknown. To resolve …

Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis,
are resistant to radiation and chemotherapy, and contribute to relapse. Although several …

Characterising the hierarchy of mammary epithelial cells (MECs) and how they are
regulated during adult development is important for understanding how breast cancer …