The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …

The transparency of the eye lens depends on maintaining the native tertiary structures and
solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of …

The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

The α-, β-and γ-crystallins are the major protein components of the vertebrate eye lens, α-
crystallin as a molecular chaperone as well as a structural protein, β-and γ-crystallins as …

The data reported in the past 5 years have highlighted new aspects of protein misfolding
and aggregation. Firstly, it appears that protein aggregation may be a generic property of …

Crystallins are the predominant structural proteins in the lens that are evolutionarily related
to stress proteins. They were first discovered outside the vertebrate eye lens by Bhat and …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

The crystallins were discovered more than 100 years ago by Mörner (1893. Untersuchungen
der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61 …

Small heat-shock proteins, including αB-crystallin (αB), play an important part in protein
homeostasis, because their ATP-independent chaperone activity inhibits uncontrolled …