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Nitric oxide signalling in cardiovascular health and disease
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Healthful aging mediated by inhibition of oxidative stress
The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …
related to the accompanying burden of debilitating diseases prevalent in the older …
New insights in cardiac β-adrenergic signaling during heart failure and aging
Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …
decreasing their survival and overall quality of life. In fact, despite the improvements in …
Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future
In contrast to the wealth of proven therapies for heart failure with reduced ejection fraction
(HFrEF), therapeutic efforts in the past have failed to improve outcomes in heart failure with …
(HFrEF), therapeutic efforts in the past have failed to improve outcomes in heart failure with …
[HTML][HTML] Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)
The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …
Natriuretic peptides in the regulation of cardiovascular physiology and metabolic events
(BNP), and C-type natriuretic peptide (CNP) are the known members of the mammalian
natriuretic peptide system. The discovery of natriuretic peptides (NPs) dates back to 1981 …
natriuretic peptide system. The discovery of natriuretic peptides (NPs) dates back to 1981 …
Adrenergic receptors in individual ventricular myocytes: the beta-1 and alpha-1B are in all cells, the alpha-1A is in a subpopulation, and the beta-2 and beta-3 are …
Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac
adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the …
adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the …
Brown adipocyte ADRB3 mediates cardioprotection via suppressing exosomal iNOS
JR Lin, LLQ Ding, L Xu, J Huang, ZB Zhang… - Circulation …, 2022 - ahajournals.org
Background: The ADRB3 (β3-adrenergic receptors), which is predominantly expressed in
brown adipose tissue (BAT), can activate BAT and improve metabolic health. Previous …
brown adipose tissue (BAT), can activate BAT and improve metabolic health. Previous …
[HTML][HTML] Modulation of the nitric oxide/cGMP pathway in cardiac contraction and relaxation: Potential role in heart failure treatment
R Mollace, F Scarano, I Bava, C Carresi… - Pharmacological …, 2023 - Elsevier
Evidence exists that heart failure (HF) has an overall impact of 1–2% in the global
population being often associated with comorbidities that contribute to increased disease …
population being often associated with comorbidities that contribute to increased disease …
[HTML][HTML] The beta3 adrenergic receptor in healthy and pathological cardiovascular tissues
The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …
the observation of its expression in white and beige human adipocytes and its implication in …