Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by impairments in social interaction and communication along with repetitive stereotypic …

The role of brain somatic mutations in Alzheimer's disease (AD) is not well understood.
Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 …

It has been established that the key metabolic pathways of glycolysis and oxidative
phosphorylation are intimately related to redox biology through control of cell signaling …

Abstract Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has
no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau …

Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for
protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons …