Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Proteolysis Targeting Chimeras (PROTACs) are attractive therapeutic modalities for
degrading disease-causing proteins. While many PROTACs have been developed for …

Small-molecule inhibitors of the CDK4/6 cell-cycle kinases have shown clinical efficacy in
estrogen receptor (ER)-positive metastatic breast cancer, although their cytostatic effects are …

Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …

The cyclin-dependent kinase CdkP associates with cyclins A, D, and E and has been
implicated in the control of the Gl to S phase transition in mammals. To identify potential …

The division cycle of eukaryotic cells is regulated by a family of protein kinases known as the
cyclin-dependent kinases (CDKs) 1, 2. The sequential activation of individual members of …

Deregulation of cell proliferation is a hallmark of neoplastic transformation. Alteration in
growth control pathways must translate into changes in the cell-cycle regulatory machinery …

A cascade of events is triggered upon the addition of growth factor to quiescent mammalian
cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase …