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The antidepressant actions of ketamine and its enantiomers
Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist first developed as an
anesthetic, has shown significant promise as a medication with rapid antidepressant …
anesthetic, has shown significant promise as a medication with rapid antidepressant …
Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis
Background Ketamine has been established as efficacious in adults living with Treatment-
resistant Depression (TRD). Toward providing a quantifiable estimate of the clinical …
resistant Depression (TRD). Toward providing a quantifiable estimate of the clinical …
Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment …
Background Bipolar depression accounts for most of the disease duration in type I and type
II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals …
II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals …
The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: a post-hoc analysis of pooled real-world data
Abstract Introduction Intravenous ketamine (KET-IV) and intranasal esketamine (ESK-NS)
are effective in the acute treatment of Treatment-Resistant Depression (TRD). Studies …
are effective in the acute treatment of Treatment-Resistant Depression (TRD). Studies …
Patient perspectives and experiences with psilocybin treatment for treatment-resistant depression: a qualitative study
Psilocybin is the most researched classic psychedelic for Treatment-Resistant Depression
(TRD). While optimizing set and setting are considered essential for efficacy and safety …
(TRD). While optimizing set and setting are considered essential for efficacy and safety …
Rethinking ketamine and esketamine action: are they antidepressants with mood-stabilizing properties?
Ketamine and esketamine, the S-enantiomer of the racemic mixture, have recently
generated considerable interest as potential therapeutic agents for Treatment-Resistant …
generated considerable interest as potential therapeutic agents for Treatment-Resistant …
[HTML][HTML] Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)
Abstract Treatment-resistant depression (TRD) represents a severe clinical condition with
high social and economic costs. Esketamine Nasal Spray (ESK-NS) has recently been …
high social and economic costs. Esketamine Nasal Spray (ESK-NS) has recently been …
[HTML][HTML] Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of …
Esketamine, the S-enantiomer of ketamine, has recently emerged as a therapy for treatment-
resistant depression (TRD), showing both rapid antidepressant action and good efficacy and …
resistant depression (TRD), showing both rapid antidepressant action and good efficacy and …
[HTML][HTML] The efficacy and safety of intranasal formulations of ketamine and esketamine for the treatment of major depressive disorder: a systematic review
Ketamine and its enantiomers represent an innovative glutamatergic agent as a treatment
for individuals with treatment-resistant depression (TRD) and major depressive disorder …
for individuals with treatment-resistant depression (TRD) and major depressive disorder …
Personalized use of ketamine and esketamine for treatment-resistant depression
A large and disproportionate portion of the burden associated with major depressive
disorder (MDD) is due to treatment-resistant depression (TRD). Intravenous (R, S)-ketamine …
disorder (MDD) is due to treatment-resistant depression (TRD). Intravenous (R, S)-ketamine …