Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

The effects of oxidative stress on female reproduction: a review

A Agarwal, A Aponte-Mellado, BJ Premkumar… - Reproductive biology …, 2012 - Springer
Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules
including reactive oxygen and nitrogen species, and antioxidant defenses, has been …

[BOOK][B] The pathology of the human placenta

K Benirschke, SG Driscoll - 1967 - Springer
This presentation of the diseases of the placenta differs in many ways from the first such
treatment in these volumes by the eminent Robert Meyer. It is a deliberate attempt to bring …

The role of inflammation in the pathology of preeclampsia

AC Harmon, DC Cornelius, LM Amaral… - Clinical …, 2016 - portlandpress.com
Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading
cause of maternal and prenatal morbidity. PE is associated with hypertension after week 20 …

The role of oxidative stress in hypertensive disorders of pregnancy (preeclampsia, gestational hypertension) and metabolic disorder of pregnancy (gestational …

WN Phoswa, OP Khaliq - Oxidative medicine and cellular …, 2021 - Wiley Online Library
Purpose of the Review. To highlight the role of oxidative stress in hypertensive disorders of
pregnancy (HDP) and metabolic disorders of pregnancy (gestational diabetes mellitus) …

Pathophysiology and current clinical management of preeclampsia

LM Amaral, K Wallace, M Owens, B LaMarca - Current hypertension …, 2017 - Springer
Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second
half of pregnancy. This disease is a major contributor to preterm and low birth weight babies …

Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia

S Ahmad, A Ahmed - Circulation research, 2004 - Am Heart Assoc
Preeclampsia is an inflammatory disorder in which serum levels of vascular endothelial
growth factor (VEGF) and its soluble receptor-1 (sVEGFR-1, also known as sFlt-1) are …