Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Metabolic rewiring underlies the effector functions of macrophages,–, but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

Metabolic alterations in the microenvironment significantly modulate tumor
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …

Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …