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A single-cell multimodal view on gene regulatory network inference from transcriptomics and chromatin accessibility data
Eukaryotic gene regulation is a combinatorial, dynamic, and quantitative process that plays
a vital role in development and disease and can be modeled at a systems level in gene …
a vital role in development and disease and can be modeled at a systems level in gene …
Single-cell EpiChem jointly measures drug–chromatin binding and multimodal epigenome
C Dong, X Meng, T Zhang, Z Guo, Y Liu, P Wu… - Nature …, 2024 - nature.com
Studies of molecular and cellular functions of small-molecule inhibitors in cancer treatment,
eliciting effects by targeting genome and epigenome associated proteins, requires …
eliciting effects by targeting genome and epigenome associated proteins, requires …
Atlas-scale single-cell DNA methylation profiling with sciMETv3
Single-cell methods to assess DNA methylation have not achieved the same level of cell
throughput per experiment compared to other modalities, with large-scale datasets requiring …
throughput per experiment compared to other modalities, with large-scale datasets requiring …
Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility
Single-cell whole-genome sequencing (scWGS) enables the assessment of genome-level
molecular differences between individual cells with particular relevance to genetically …
molecular differences between individual cells with particular relevance to genetically …
Integration of single-cell transcriptome and chromatin accessibility and its application on tumor investigation
C Yang, Y **, Y Yin - Life Medicine, 2024 - academic.oup.com
The advent of single-cell sequencing techniques has not only revolutionized the
investigation of biological processes but also significantly contributed to unraveling cellular …
investigation of biological processes but also significantly contributed to unraveling cellular …
Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-GF Knock in Mouse Model
Detecting and understanding the early stages of Alzheimer's disease (AD) is essential for
uncovering initial mechanisms of neuropathology and devising effective interventions. In this …
uncovering initial mechanisms of neuropathology and devising effective interventions. In this …
[HTML][HTML] 单细胞测序在干细胞生物学中的应用研究进展
肖邦， 朱静， 徐莎， 陈国栋， 黄超 - 海军军医大学学报, 2023 - html.rhhz.net
细胞间的变异或异质性是干细胞群的基本和内在特征. 传统的组学分析在混合细胞群体上进行,
导致这些差异被掩盖. **年来, 单细胞基因组, 表观基因组, 转录组测序等技术发展迅速 …
导致这些差异被掩盖. **年来, 单细胞基因组, 表观基因组, 转录组测序等技术发展迅速 …