[HTML][HTML] Multimodal experimental studies of the passive mechanical behavior of human aortas: Current approaches and future directions

A Pukaluk, G Sommer, GA Holzapfel - Acta Biomaterialia, 2024 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide and include, among
others, critical conditions of the aortic wall. Importantly, such critical conditions require …

Microstructure-based biomechanics of coronary arteries in health and disease

H Chen, GS Kassab - Journal of biomechanics, 2016 - Elsevier
Coronary atherosclerosis is the major cause of mortality and disability in developed nations.
A deeper understanding of mechanical properties of coronary arteries and hence their …

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion

KM Stearns‐Reider, A D'Amore, K Beezhold… - Aging cell, 2017 - Wiley Online Library
Age‐related declines in skeletal muscle regeneration have been attributed to muscle stem
cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis …

Microstructural and mechanical characterization of the layers of human descending thoracic aortas

M Amabili, M Asgari, ID Breslavsky, G Franchini… - Acta Biomaterialia, 2021 - Elsevier
The mechanical properties of human aortas are linked to the layered tissue and its
microstructure at different length scales. Each layer has specific mechanical and structural …

Bi-layered polyurethane–extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

A D'Amore, T Yoshizumi, SK Luketich, MT Wolf, X Gu… - Biomaterials, 2016 - Elsevier
As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a
temporary, local patch to the surface of the recently infarcted ventricle has been explored …

[HTML][HTML] Changes in the microstructure of the human aortic adventitia under biaxial loading investigated by multi-photon microscopy

A Pukaluk, H Wolinski, C Viertler, P Regitnig… - Acta Biomaterialia, 2023 - Elsevier
Among the three layers of the aortic wall, the media is primarily responsible for its
mechanical properties, but the adventitia prevents the aorta from overstretching and …

Role of smooth muscle activation in the static and dynamic mechanical characterization of human aortas

G Franchini, ID Breslavsky, F Giovanniello… - Proceedings of the …, 2022 - pnas.org
Experimental data and a suitable material model for human aortas with smooth muscle
activation are not available in the literature despite the need for develo** advanced grafts; …

Development and mechanical characterization of decellularized scaffolds for an active aortic graft

F Giovanniello, M Asgari, ID Breslavsky, G Franchini… - Acta Biomaterialia, 2023 - Elsevier
Decellularized porcine aortas are proposed as scaffolds for revolutionary active aortic grafts.
A change in the static and dynamic mechanical properties, associated with the …

Differences in collagen fiber diameter and waviness between healthy and aneurysmal abdominal aortas

JA Niestrawska, A Pukaluk, AR Babu… - Microscopy and …, 2022 - academic.oup.com
Collagen plays a key role in the strength of aortic walls, so studying micro-structural changes
during disease development is critical to better understand collagen reorganization. Second …

A comprehensive study of layer-specific morphological changes in the microstructure of carotid arteries under uniaxial load

W Krasny, C Morin, H Magoariec, S Avril - Acta biomaterialia, 2017 - Elsevier
The load bearing properties of large blood vessels are principally conferred by collagen and
elastin networks and their microstructural organization plays an important role in the …