Inflammasomes in alveolar bone loss

Y Li, J Ling, Q Jiang - Frontiers in immunology, 2021 - frontiersin.org
Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Oral mucosal epithelial cells

S Groeger, J Meyle - Frontiers in immunology, 2019 - frontiersin.org
Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

R Cheng, Z Wu, M Li, M Shao, T Hu - International journal of oral …, 2020 - nature.com
Abstract Interleukin (IL)-1β, a pro-inflammatory cytokine, was elevated and participates in
periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical …

Periodontitis activates the NLRP3 inflammasome in serum and saliva

G Isola, A Polizzi, S Santonocito… - Journal of …, 2022 - Wiley Online Library
Background Nod‐like receptor family pyrin domain‐containing protein‐3 (NLRP3) complex
inflammasome has potentially been shown to play an important role in the development of …

Chronic inflammation as a link between periodontitis and carcinogenesis

A Hoare, C Soto, V Rojas-Celis… - Mediators of …, 2019 - Wiley Online Library
Periodontitis is characterized by a chronic inflammation produced in response to a disease‐
associated multispecies bacterial community in the subgingival region. Although the …

Metabolic regulation of inflammation

T Gaber, C Strehl, F Buttgereit - Nature Reviews Rheumatology, 2017 - nature.com
Immune cells constantly patrol the body via the bloodstream and migrate into multiple
tissues where they face variable and sometimes demanding environmental conditions …

Breaking bad: Manipulation of the host response by Porphyromonas gingivalis

G Hajishengallis, RJ Lamont - European journal of immunology, 2014 - Wiley Online Library
Recent metagenomic and mechanistic studies are consistent with a new model of
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …

How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?

PM Preshaw, JJ Taylor - Journal of clinical periodontology, 2011 - Wiley Online Library
Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …

Porphyromonas gingivalis survival skills: Immune evasion

S Zheng, S Yu, X Fan, Y Zhang, Y Sun… - Journal of …, 2021 - Wiley Online Library
Periodontitis is a chronic inflammatory condition that destroys the tooth‐supporting tissues
and eventually leads to tooth loss. As one of the most prevalent oral conditions, periodontitis …