Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

V (D) J recombination proceeds through a series of protein: DNA complexes mediated in
part by the RAG1 and RAG2 proteins. These proteins are responsible for sequence-specific …

XRCC4 was identified via a complementation cloning method that employed an ionizing
radiation (IR)-sensitive hamster cell line. By gene-targeted mutation, we show that XRCC4 …

The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V (D)
J recombination, the process by which immunoglobulin and T-cell antigen-receptor genes …

Some species mount a robust antibody response despite having limited genome-encoded
combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 …

The catalytic subunit of DNA‐dependent protein kinase (DNA‐PK CS) is required for a non‐
homologous end‐joining pathway that repairs DNA double‐strand breaks produced by …

DNA double strand breaks (DSBs) 1 may be the most disruptive form of DNA damage. If left
unrepaired, they lead to broken chromosomes and cell death. If repaired improperly, they …

Human X‐box binding protein‐1 (XBP1) is an alternatively spliced transcription factor that
participates in the unfolded protein response (UPR), a stress‐signaling pathway that allows …

In mammalian cells, double-strand break repair and V (D) J recombination require DNA-
dependent protein kinase (DNA-PK), a serine/threonine kinase that is activated by DNA …

DNA repair systems act to maintain genome integrity in the face of replication errors,
environmental insults, and the cumulative effects of age. More than 70 human genes directly …