Recent work in structural biology is shedding light on how many of the enzymes of
intermediary metabolism are self-and co-assembling into large, filamentous polymers or …

The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP
synthase (CTPS). As a textbook enzyme, CTPS has been extensively studied for seven …

Targeting nucleotide biosynthesis is a proven strategy for the treatment of cancer but is
limited by toxicity, reflecting the fundamental nucleotide requirement of dividing cells. The …

Many metabolic enzymes self-assemble into micron-scale filaments to organize and
regulate metabolism. The appearance of these assemblies often coincides with large …

Ethnopharmacological relevance Tetradium ruticarpum (A. Juss.) TG Hartley is a traditional
Chinese medicine with a history of thousands of years, which plays an important role in the …

The CTP nucleotide is a key precursor of nucleic acids metabolism essential for DNA
replication. De novo CTP production relies on CTP synthetases 1 and 2 (CTPS1 and …

Lymphoma is the most common hematological malignancy and is among the 10 most
prevalent cancers worldwide. Although survival has been improved by modern …

Nucleotides are synthesized through two distinct pathways: de novo synthesis and
nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino …

The cellular compartmentation induced by self-assembly of natural proteins has recently
attracted widespread attention due to its structural–functional significance. Among them, as …

The cytoophidium, composed mainly of CTP synthase (CTPS), is a newly discovered
dynamic filamentous structure in various organisms such as archaea, bacteria, and humans …