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Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker
Z Yang, KKW Wang - Trends in neurosciences, 2015 - cell.com
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found
in astrocytes in the central nervous system (CNS), non-myelinating Schwann cells in the …
in astrocytes in the central nervous system (CNS), non-myelinating Schwann cells in the …
GFAP in health and disease
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000)
LF Eng, RS Ghirnikar, YL Lee - Neurochemical research, 2000 - Springer
It is now well established that the glial fibrillary acidic protein (GFAP) is the principal 8–9 nm
intermediate filament in mature astrocytes of the central nervous system (CNS). Over a …
intermediate filament in mature astrocytes of the central nervous system (CNS). Over a …
GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease
W Kamphuis, C Mamber, M Moeton, L Kooijman… - 2012 - journals.plos.org
Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP
splice isoforms show differential expression patterns in the human brain. GFAPδ is …
splice isoforms show differential expression patterns in the human brain. GFAPδ is …
[HTML][HTML] Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease
W Kamphuis, J Middeldorp, L Kooijman, JA Sluijs… - Neurobiology of …, 2014 - Elsevier
In Alzheimer's disease (AD), amyloid plaques are surrounded by reactive astrocytes with an
increased expression of intermediate filaments including glial fibrillary acidic protein (GFAP) …
increased expression of intermediate filaments including glial fibrillary acidic protein (GFAP) …
GFAP at 50
A Messing, M Brenner - ASN neuro, 2020 - journals.sagepub.com
Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by
Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament …
Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament …
Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
D Woodbury, K Reynolds… - Journal of neuroscience …, 2002 - Wiley Online Library
Bone marrow stromal stem cells (MSCs) normally differentiate into mesenchymal derivatives
but recently have also been converted into neurons, classical ectodermal cells. To begin …
but recently have also been converted into neurons, classical ectodermal cells. To begin …
Alexander disease
A Messing, M Brenner, MB Feany… - Journal of …, 2012 - jneurosci.org
1The past decade has witnessed a burst of speculation and data about how astrocyte
dysfunction contributes to the phenotypes of the well known neurodegenerative diseases …
dysfunction contributes to the phenotypes of the well known neurodegenerative diseases …
Enteric GFAP expression and phosphorylation in Parkinson's disease
T Clairembault, W Kamphuis… - Journal of …, 2014 - Wiley Online Library
Enteric glial cells (EGC s) are in many respects similar to astrocytes of the central nervous
system and express similar proteins including glial fibrillary acidic protein (GFAP). Changes …
system and express similar proteins including glial fibrillary acidic protein (GFAP). Changes …
GFAP and its role in Alexander disease
RA Quinlan, M Brenner, JE Goldman… - Experimental cell research, 2007 - Elsevier
Here we review how GFAP mutations cause Alexander disease. The current data suggest
that a combination of events cause the disease. These include:(i) the accumulation of GFAP …
that a combination of events cause the disease. These include:(i) the accumulation of GFAP …