At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Molecular probes that change their signals in response to the target of interest have a critical
role in fundamental biology and medicine. Semiconducting polymer nanoparticles (SPNs) …

Oxidative stress (OS) plays an important role in the pathology of certain human diseases.
Scientists have developed great interest regarding the determination of oxidative stress …

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …

Cell adaptation to hypoxia (Hyp) requires activation of transcriptional programs that
coordinate expression of genes involved in oxygen delivery (via angiogenesis) and …

We report that mitochondrial DNA (mtDNA) is inflammatogenic in vitro and in vivo as a result
of the presence of unmethylated CpG sequences and its oxidative status. Purified human …

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in coordinating
innate and adaptive immunity, inflammation, and apoptotic cell death. NF-κB is activated by …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Entry of monocytes into the vessel wall is an important event in atherogenesis. Previous
studies from our laboratory suggest that oxidized arachidonic acid-containing phospholipids …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …