From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …
women and men, but epidemiological evidence in humans and recent mechanistic studies …
The protective effects of estrogen on the cardiovascular system
ME Mendelsohn, RH Karas - New England journal of medicine, 1999 - Mass Medical Soc
The incidence of cardiovascular disease differs significantly between men and women, in
part because of differences in risk factors and hormones. 1 The incidence of atherosclerotic …
part because of differences in risk factors and hormones. 1 The incidence of atherosclerotic …
The complex role of estrogens in inflammation
There is still an unresolved paradox with respect to the immunomodulating role of estrogens.
On one side, we recognize inhibition of bone resorption and suppression of inflammation in …
On one side, we recognize inhibition of bone resorption and suppression of inflammation in …
Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
We have investigated the differential mitochondrial oxidative stress between males and
females to understand the molecular mechanisms enabling females to live longer than …
females to understand the molecular mechanisms enabling females to live longer than …
[HTML][HTML] Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but
whether and how they may influence each others negative impact on bone remains …
whether and how they may influence each others negative impact on bone remains …
A crucial role for thiol antioxidants in estrogen-deficiency bone loss
JM Lean, JT Davies, K Fuller, CJ Jagger… - The Journal of clinical …, 2003 - jci.org
The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere,
estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS …
estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS …
Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective
Nitric oxide (NO) affects two key aspects of O2 supply and demand: It regulates vascular
tone and blood flow by activating soluble guanylate cyclase (sGC) in the vascular smooth …
tone and blood flow by activating soluble guanylate cyclase (sGC) in the vascular smooth …
Modulation of antioxidant enzyme expression and function by estrogen
K Strehlow, S Rotter, S Wassmann, O Adam… - Circulation …, 2003 - ahajournals.org
Oxidative stress plays a pivotal role in the pathogenesis of atherosclerosis and can be
effectively influenced by radical scavenging enzyme activity and expression. The …
effectively influenced by radical scavenging enzyme activity and expression. The …
Apoptosis in the vasculature: mechanisms and functional importance
Apoptotic death has now been recognized in a number of common and threatening vascular
diseases, including atherosclerosis. Interest in apoptosis research relates to the fact that …
diseases, including atherosclerosis. Interest in apoptosis research relates to the fact that …
Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium
S Kerr, MJ Brosnan, M McIntyre, JL Reid… - …, 1999 - ahajournals.org
The hypothesis that the decreased nitric oxide (NO) availability observed in spontaneously
hypertensive stroke-prone rats (SHRSP) is due to excess superoxide (O2−) was examined …
hypertensive stroke-prone rats (SHRSP) is due to excess superoxide (O2−) was examined …