Ventricular tachycardia in nonischemic heart failure (HF) initiates by a nonreentrant
mechanism that appears to be due to triggered activity primarily from delayed …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Background—Adeno-associated virus type 1/sarcoplasmic reticulum Ca2+-ATPase was
assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with …

There is much evidence showing that some lethal ventricular arrhythmias arise from waves
of Ca2+ release from the sarcoplasmic reticulum (SR) that propagate along cardiac cells …

The cardiac isoform of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) plays a
major role in controlling excitation/contraction coupling. In both experimental and clinical …

Background—Ventricular arrhythmias are life-threatening complications of heart failure and
myocardial ischemia. Increased diastolic Ca2+ overload occurring in ischemia leads to …

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …

The antidiabetic agent class of sodium-glucose cotransporter 2 (SGLT2) inhibitors confer
unprecedented cardiovascular benefits beyond glycemic control, including reducing the risk …

Ca 2+, the main second messenger, is central to the regulation of cellular growth. There is
increasing evidence that cellular growth and proliferation are supported by a continuous …

Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco (endo) plasmic reticulum
Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and …