Folate metabolism: a re-emerging therapeutic target in haematological cancers
Folate-mediated one carbon (1C) metabolism supports a series of processes that are
essential for the cell. Through a number of interlinked reactions happening in the cytosol …
essential for the cell. Through a number of interlinked reactions happening in the cytosol …
FLT3 inhibitors and novel therapeutic strategies to reverse AML resistance: An updated comprehensive review
FMS-like tyrosine kinase 3 (FLT3) mutations occur in almost 30% of acute myeloid leukemia
(AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML …
(AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML …
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
A ferroptosis-inducing and leukemic cell-targeting drug nanocarrier formed by redox-responsive cysteine polymer for acute myeloid leukemia therapy
Y Yu, Y Meng, X Xu, T Tong, C He, L Wang, K Wang… - ACS …, 2023 - ACS Publications
Ferroptosis is an alternative strategy to overcome chemoresistance, but effective therapeutic
approaches to induce ferroptosis for acute myeloid leukemia (AML) treatment are limited …
approaches to induce ferroptosis for acute myeloid leukemia (AML) treatment are limited …
[HTML][HTML] NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia
S Zhang, F Huang, Y Wang, Y Long, Y Li, Y Kang… - Nature Cell …, 2024 - nature.com
RNA modification has emerged as an important epigenetic mechanism that controls
abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of …
abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of …
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Resistance to standard and novel therapies remains the main obstacle to cure in acute
myeloid leukaemia (AML) and is often driven by metabolic adaptations which are …
myeloid leukaemia (AML) and is often driven by metabolic adaptations which are …
Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets
SK Mishra, SE Millman, L Zhang - Blood, 2023 - ashpublications.org
Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions
Using a genome-wide CRISPR screen, we identified CDK9, DHODH, and PRMT5 as
synthetic lethal partners with gilteritinib treatment in fms-like tyrosine kinase 3 (FLT3) …
synthetic lethal partners with gilteritinib treatment in fms-like tyrosine kinase 3 (FLT3) …
IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD+ acute myeloid leukemia
S Wu, C Chi, S Weng, W Zhou, Z Liu - Apoptosis, 2023 - Springer
Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD),
accounting for about 25% of AML patients. The expression of DANCR in FLT3-ITD AML had …
accounting for about 25% of AML patients. The expression of DANCR in FLT3-ITD AML had …
Synthetic lethal strategies for the development of cancer therapeutics
Synthetic lethality is a genetic phenomenon whereby the simultaneous presence of two
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …