Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers

H Jeltsch-David, S Muller - Nature Reviews Neurology, 2014 - nature.com
Systemic lupus erythematosus (SLE) is a complex clinical syndrome, elements of which
remain poorly understood. Although recognized over 140 years ago when Kaposi recorded …

[HTML][HTML] Machine learning application in autoimmune diseases: State of art and future prospectives

MG Danieli, S Brunetto, L Gammeri, D Palmeri… - Autoimmunity …, 2024 - Elsevier
Autoimmune diseases are a group of disorders resulting from an alteration of immune
tolerance, characterized by the formation of autoantibodies and the consequent …

Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives

C Magro-Checa, EJ Zirkzee, TW Huizinga… - Drugs, 2016 - Springer
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a generic definition referring to a
series of neurological and psychiatric symptoms directly related to systemic lupus …

The diagnosis and clinical management of the neuropsychiatric manifestations of lupus

M Govoni, A Bortoluzzi, M Padovan, E Silvagni… - Journal of …, 2016 - Elsevier
Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?

M Govoni, JG Hanly - Rheumatology, 2020 - academic.oup.com
Neuropsychiatric (NP) events occur in the majority of patients with SLE and predominantly
affect the CNS in addition to the peripheral and autonomic systems. Approximately 30% of …

Central nervous system systemic lupus erythematosus: pathophysiologic, clinical, and imaging features

Y Ota, A Srinivasan, AA Capizzano, JR Bapuraj… - Radiographics, 2022 - pubs.rsna.org
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by
multiple immunologic abnormalities and has the potential to involve the central nervous …

Fibrosis imaging: current concepts and future directions

M Baues, A Dasgupta, J Ehling, J Prakash… - Advanced drug delivery …, 2017 - Elsevier
Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of …

D Cohen, EC Rijnink, RJA Nabuurs… - …, 2016 - academic.oup.com
Objectives. Neuropsychiatric (NP) involvement is a poorly understood manifestation of SLE.
We studied post-mortem histopathology in relation to clinical NPSLE syndromes and …

Brain-reactive autoantibodies in neuropsychiatric systemic lupus erythematosus

C Cocco, E Manca, G Corda, MM Angioni… - Frontiers in …, 2023 - frontiersin.org
Introduction The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) is
widely unknown, and the role of autoantibodies is still undetermined. Methods To identify …