Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Most methods for the analysis of oligosaccharides from biological sources require a glycan
derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore …

Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …

Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …

Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …

Sialylated human milk oligosaccharides (SHMOs) are important components of human milk
oligosaccharides. Sialic acids are typically found on the nonreducing end and are known …

The characterization of glycosylation is critical for obtaining a comprehensive view of the
regulation and functions of glycoproteins of interest. Due to the complex nature of …

The diversity of stereochemical isomers present in glycans and glycoconjugates poses a
formidable challenge for comprehensive structural analysis. Typically, sophisticated mass …

Protein biopharmaceuticals such as monoclonal antibodies and therapeutic proteins are
currently in widespread use for the treatment of various life-threatening diseases including …

Porous graphitised carbon-liquid chromatography (PGC-LC) has been proven to be a
powerful technique for the analysis and characterisation of complex mixtures of isomeric and …