Role of the parasympathetic nervous system in cancer initiation and progression

M Tibensky, B Mravec - Clinical and Translational Oncology, 2021 - Springer
The nervous system plays an important role in cancer initiation and progression.
Accumulated evidences clearly show that the sympathetic nervous system exerts stimulatory …

Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node

N Shrestha, K Zorn-Pauly, P Mesirca… - Proceedings of the …, 2023 - National Acad Sciences
Sepsis has emerged as a global health burden associated with multiple organ dysfunction
and 20% mortality rate in patients. Numerous clinical studies over the past two decades …

Bradyarrhythmias in patients with SARS‐CoV‐2 infection: A narrative review and a clinical report

MC Gatto, A Persi, M Tung, R Masi… - Pacing and Clinical …, 2021 - Wiley Online Library
Several cardiovascular diseases and arrhythmic disorders have been described in COVID‐
19 era as likely related to SARS‐CoV‐2 infection. The prognostic relevance of …

Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype long Coronavirus disease 2019

MS Durstenfeld, MJ Peluso, P Kaveti… - The Journal of …, 2023 - academic.oup.com
Background Mechanisms underlying persistent cardiopulmonary symptoms after severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (postacute sequelae of …

[HTML][HTML] Relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan

K Ikeuchi, M Saito, S Yamamoto, H Nagai… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
Coronavirus disease is reported to affect the cardiovascular system. We showed that relative
bradycardia was a common characteristic for 54 patients with PCR-confirmed mild-to …

Endotoxemia is associated with partial uncoupling of cardiac pacemaker from cholinergic neural control in rats

M Gholami, P Mazaheri, A Mohamadi, T Dehpour… - Shock, 2012 - journals.lww.com
Cardiac cycle is regulated by a complex interplay between autonomic nervous system and
cardiac pacemaker cells. Decreased heart rate variability (HRV) and increased cardiac …

Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis

DB Hoover, TR Ozment, R Wondergem, C Li… - Shock, 2015 - journals.lww.com
The scope of cardiac pathophysiology in sepsis has not been fully defined. Accordingly, we
evaluated the effects of sepsis on heart rate (HR), HR variability, and conduction parameters …

Inflammation during early post-acute COVID-19 is associated with reduced exercise capacity and Long COVID symptoms after 1 year

MS Durstenfeld, MJ Peluso, P Kaveti, C Hill, D Li… - medRxiv, 2022 - medrxiv.org
BACKGROUND Mechanisms underlying persistent cardiopulmonary symptoms following
SARS-CoV-2 infection (post-acute sequelae of COVID-19 “PASC” or “Long COVID”) remain …

Decreased cardio-respiratory information transfer is associated with deterioration and a poor prognosis in critically ill patients with sepsis

C Morandotti, M Wikner, Q Li, E Ito… - Journal of Applied …, 2025 - journals.physiology.org
Assessing illness severity in the intensive care unit (ICU) is crucial for early prediction of
deterioration and prognosis. Traditional prognostic scores often treat organ systems …

Additive counteraction by α7 and α4β2-nAChRs of the hypotension and cardiac sympathovagal imbalance evoked by endotoxemia in male rats

MY Sallam, SM El-Gowilly, HM El-Gowelli… - European Journal of …, 2018 - Elsevier
The cholinergic antiinflammatory pathway favorably influences end organ damage induced
by inflammatory conditions. Here, we hypothesized that α7 and/or α4β2-nicotinic …