Parkinson disease (PD) is characterized by heterogeneous motor and non-motor symptoms,
resulting from neurodegeneration involving various parts of the central nervous system …

Diverse but complementary methodologies are required to uncover the complex
determinants and pathophysiology of freezing of gait. To develop future therapeutic …

Gait and balance abnormalities develop commonly in Parkinson's disease and are among
the motor symptoms most disabling and refractory to dopaminergic or other treatments …

Objective Freezing of gait (FOG) is a common disabling motor symptom in Parkinson's
disease (PD), but the potential pathogenic mechanisms are still unclear. Methods A total of …

Freezing of gait (FOG) is a paroxysmal gait disorder that often occurs at advanced stages of
Parkinson's disease (PD). FOG consists of abrupt walking interruption and severe difficulty in …

ABSTRACT Introduction Freezing of gait (FoG) is one of the most disabling yet poorly
understood symptoms of Parkinson's disease (PD). FoG is an episodic gait pattern …

Deep brain stimulation (DBS) conventionally target at basal ganglia or thalamic structures,
modulating nodal points in the cortico-basal ganglia circuit, in order to effectively treat …

Freezing of gait (FoG) is a paroxysmal and sporadic gait impairment that severely affects PD
patients' quality of life. This review summarizes current neuroimaging investigations that …

Background Although dysfunction of large-scale brain networks has been frequently
demonstrated in patients with α-Synucleinopathy (α-Syn, ie, Parkinson's disease, dementia …

Amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder
characterized by progressive degeneration of upper motor neurons and lower motor …