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The cross-links of endoplasmic reticulum stress, autophagy, and neurodegeneration in Parkinson's disease
H Ren, W Zhai, X Lu, G Wang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and it
is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra …
is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra …
GRP78 as a potential therapeutic target in cancer treatment: An updated review of its role in chemoradiotherapy resistance of cancer cells
M Lin, Y Mo, C Li, Y Liu, X Feng - Medical Oncology, 2025 - Springer
Abstract GRP78 (Glucose-related protein 78, BiP/HSPA5) is commonly overexpressed in
cancer cells. Acting as an activator of endoplasmic reticulum stress, GRP78 is involved in …
cancer cells. Acting as an activator of endoplasmic reticulum stress, GRP78 is involved in …
Melatonin analogues potently inhibit MAO-B and protect PC12 cells against oxidative stress
Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in
oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a …
oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a …
UBA52 attunes VDAC1-mediated mitochondrial dysfunction and dopaminergic neuronal death
S Tiwari, A Singh, P Gupta, AK… - ACS Chemical …, 2023 - ACS Publications
Mitochondrial homeostasis regulates energy metabolism, calcium buffering, cell function,
and apoptosis. The present study has been conducted to investigate the implications of the …
and apoptosis. The present study has been conducted to investigate the implications of the …
4-Phenylbutyrate mitigates the motor impairment and dopaminergic neuronal death during Parkinson's disease pathology via targeting VDAC1 mediated …
S Tiwari, P Gupta, A Singh, S Chaturvedi… - Neurochemical …, 2022 - Springer
Parkinson's disease (PD) is a progressive motor neurodegenerative disorder significantly
associated with protein aggregation related neurodegenerative mechanisms. In view of no …
associated with protein aggregation related neurodegenerative mechanisms. In view of no …
Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice
The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease
Alzheimer's disease (AD) pathology is characterized by cognitive impairment, increased
acetylcholinesterase (AChE) activity, and impaired neuronal communication. Clinically …
acetylcholinesterase (AChE) activity, and impaired neuronal communication. Clinically …
Salubrinal ameliorates inflammation and neovascularization via the caspase 3/Enos signaling in an alkaline-induced rat corneal neovascularization model
Background and Objectives: Ocular alkaline burn is a clinical emergency that can cause
permanent vision loss due to limbal stem cell deficiency and corneal neovascularization …
permanent vision loss due to limbal stem cell deficiency and corneal neovascularization …
Cardinal role of eukaryotic initiation factor 2 (eIF2α) in progressive dopaminergic neuronal death & DNA fragmentation: Implication of PERK: IRE1α: ATF6 axis in …
The study was conducted to assess the role of eukaryotic initiation factor 2 (eIF2α) in
progressive dopaminergic neuronal death employing various interventions (YM08, 4μ8C …
progressive dopaminergic neuronal death employing various interventions (YM08, 4μ8C …
Reciprocal upshot of nitric oxide, endoplasmic reticulum stress, and ubiquitin proteasome system in Parkinson's disease pathology
S Tiwari, S Singh - The Neuroscientist, 2021 - journals.sagepub.com
Parkinson's disease (PD) pathology involves degeneration of nigrostriatal pathway,
postulating symptoms associated with age, environment, and genetic anomalies, including …
postulating symptoms associated with age, environment, and genetic anomalies, including …