The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Necrosis in the tumor interior is a common feature of aggressive cancers that is associated
with poor clinical prognosis and the development of metastasis. How the necrotic core …

Multiple bone marrow stromal cell types have been identified as hematopoietic stem cell
(HSC)-regulating niche cells,,,,,,. However, whether HSC progeny can serve directly as HSC …

Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying
drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 …

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …

Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …

Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …

Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of
lipids. Inactivation of ANGPTL3, a gene located in an intron of DOCK7, results in very low …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …