Due to their fundamental role in energy production, mitochondria have been traditionally
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …

Autophagy is a catabolic pathway by which cellular components are delivered to the
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …

Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors,
hypoxia is associated with aggressive disease course and poor clinical outcomes …

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by
conducting different omics data analyses, we demonstrated that cisplatin induces cell death …

Pluripotent stem cells hold significant promise in regenerative medicine due to their
unlimited capacity for self-renewal and potential to differentiate into any cell type of the body …

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …

The generation of induced pluripotent stem cells (iPSC) has enormous potential for the
development of patient-specific regenerative medicine. Human embryonic stem cells (hESC) …

Evolutionary theory predicts that cellular maintenance, stress defense, and DNA repair
mechanisms should be most active in germ line cells, including embryonic stem cells that …

Mitochondria undergo frequent morphological changes through fission and fusion.
Mutations in core members of the mitochondrial fission/fusion machinery are responsible for …

Autophagy is a lysosome-dependent degradation pathway that allows cells to recycle
damaged or superfluous cytoplasmic content, such as proteins, organelles, and lipids. As a …