Progress in the Chemistry of Tetrahydroquinolines

I Muthukrishnan, V Sridharan, JC Menendez - Chemical reviews, 2019 - ACS Publications
Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

Oxidative cyclization in natural product biosynthesis

MC Tang, Y Zou, K Watanabe, CT Walsh… - Chemical …, 2017 - ACS Publications
Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Biosynthesis of fungal meroterpenoids

Y Matsuda, I Abe - Natural product reports, 2016 - pubs.rsc.org
Covering: up to September 2015 Meroterpenoids are hybrid natural products that partially
originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite …

FAD-dependent enzyme-catalysed intermolecular [4+ 2] cycloaddition in natural product biosynthesis

L Gao, C Su, X Du, R Wang, S Chen, Y Zhou, C Liu… - Nature Chemistry, 2020 - nature.com
Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

Biosynthesis of cyclopropane in natural products

S Ma, D Mandalapu, S Wang, Q Zhang - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

JD Rudolf, CY Chang - Natural product reports, 2020 - pubs.rsc.org
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Prenyltransferases as key enzymes in primary and secondary metabolism

J Winkelblech, A Fan, SM Li - Applied microbiology and biotechnology, 2015 - Springer
Attachment of isoprene units to various acceptors by prenylation plays an important role in
primary and secondary metabolism of living organisms. Protein prenylation belongs to …

Hunting for the Intermolecular Diels–Alderase

L Gao, Q Ding, X Lei - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The Diels–Alder reaction is well known as a concerted [4+ 2] cycloaddition
governed by the Woodward–Hoffmann rules. Since Prof. Otto Diels and his student Kurt …

Biosynthesis of cosmosporasides reveals the assembly line for fungal hybrid terpenoid saccharides

GY Yuan, JM Zhang, QD Xu, HR Zhang… - Angewandte …, 2023 - Wiley Online Library
Fungal hybrid terpenoid saccharides constitute a new and growing family of natural products
with significant biomedical and agricultural activities. One representative family is the …

Diaporisoindoles A–C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3

H Cui, Y Lin, M Luo, Y Lu, X Huang, Z She - Organic letters, 2017 - ACS Publications
Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, and an unusual
diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) …