[HTML][HTML] Automated methods for cell type annotation on scRNA-seq data

G Pasquini, JER Arias, P Schäfer… - Computational and …, 2021 - Elsevier
The advent of single-cell sequencing started a new era of transcriptomic and genomic
research, advancing our knowledge of the cellular heterogeneity and dynamics. Cell type …

Harnessing artificial intelligence in multimodal omics data integration: paving the path for the next frontier in precision medicine

Y Nam, J Kim, SH Jung, J Woerner… - Annual Review of …, 2024 - annualreviews.org
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

AR Ringel, Q Szabo, AM Chiariello, K Chudzik… - Cell, 2022 - cell.com
Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs

I Abugessaisa, JA Ramilowski, M Lizio… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has
continued to provide extensive resources in the pursuit of understanding the transcriptome …

[HTML][HTML] Innovation, conservation, and repurposing of gene function in root cell type development

K Kajala, M Gouran, L Shaar-Moshe, GA Mason… - Cell, 2021 - cell.com
Plant species have evolved myriads of solutions, including complex cell type development
and regulation, to adapt to dynamic environments. To understand this cellular diversity, we …

Coexpression reveals conserved gene programs that co-vary with cell type across kingdoms

M Crow, H Suresh, J Lee, J Gillis - Nucleic Acids Research, 2022 - academic.oup.com
What makes a mouse a mouse, and not a hamster? Differences in gene regulation between
the two organisms play a critical role. Comparative analysis of gene coexpression networks …

Long non-coding RNAs in Sjögren's disease

O Pastva, K Klein - International journal of molecular sciences, 2024 - mdpi.com
Sjögren's disease (SjD) is a heterogeneous autoimmune disease characterized by severe
dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain …

[HTML][HTML] Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types

CW Yip, CC Hon, K Yasuzawa, DM Sivaraman… - Cell reports, 2022 - cell.com
Within the scope of the FANTOM6 consortium, we perform a large-scale knockdown of 200
long non-coding RNAs (lncRNAs) in human induced pluripotent stem cells (iPSCs) and …

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

HH Parent, CM Niswender - Molecular Pharmacology, 2024 - Elsevier
ABSTRACT Metabotropic glutamate receptor 7 (mGlu 7) is the most highly conserved and
abundantly expressed mGlu receptor in the human brain. The presynaptic localization of …

ZENBU-Reports: a graphical web-portal builder for interactive visualization and dissemination of genome-scale data

J Severin, S Agrawal, JA Ramilowski… - NAR Genomics and …, 2023 - academic.oup.com
In the genomic era, data dissemination and visualization is an integral part of scientific
publications and research projects involving international consortia producing massive …