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[HTML][HTML] Automated methods for cell type annotation on scRNA-seq data
The advent of single-cell sequencing started a new era of transcriptomic and genomic
research, advancing our knowledge of the cellular heterogeneity and dynamics. Cell type …
research, advancing our knowledge of the cellular heterogeneity and dynamics. Cell type …
Harnessing artificial intelligence in multimodal omics data integration: paving the path for the next frontier in precision medicine
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …
unclear how their integrity is maintained when incorporating novel genes and functions …
FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs
Abstract The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has
continued to provide extensive resources in the pursuit of understanding the transcriptome …
continued to provide extensive resources in the pursuit of understanding the transcriptome …
[HTML][HTML] Innovation, conservation, and repurposing of gene function in root cell type development
Plant species have evolved myriads of solutions, including complex cell type development
and regulation, to adapt to dynamic environments. To understand this cellular diversity, we …
and regulation, to adapt to dynamic environments. To understand this cellular diversity, we …
Coexpression reveals conserved gene programs that co-vary with cell type across kingdoms
What makes a mouse a mouse, and not a hamster? Differences in gene regulation between
the two organisms play a critical role. Comparative analysis of gene coexpression networks …
the two organisms play a critical role. Comparative analysis of gene coexpression networks …
Long non-coding RNAs in Sjögren's disease
Sjögren's disease (SjD) is a heterogeneous autoimmune disease characterized by severe
dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain …
dryness of mucosal surfaces, particularly the mouth and eyes; fatigue; and chronic pain …
[HTML][HTML] Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types
Within the scope of the FANTOM6 consortium, we perform a large-scale knockdown of 200
long non-coding RNAs (lncRNAs) in human induced pluripotent stem cells (iPSCs) and …
long non-coding RNAs (lncRNAs) in human induced pluripotent stem cells (iPSCs) and …
Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders
ABSTRACT Metabotropic glutamate receptor 7 (mGlu 7) is the most highly conserved and
abundantly expressed mGlu receptor in the human brain. The presynaptic localization of …
abundantly expressed mGlu receptor in the human brain. The presynaptic localization of …
ZENBU-Reports: a graphical web-portal builder for interactive visualization and dissemination of genome-scale data
In the genomic era, data dissemination and visualization is an integral part of scientific
publications and research projects involving international consortia producing massive …
publications and research projects involving international consortia producing massive …